Digoxin and cardiac contractility
Digoxin inhibits the Na+/K+-ATPase in cardiac muscle and increases contraction strength. What is the mechanism?
Answer C: explanation for every choice
A
Digoxin doesn't act directly on L-type channels.
B
Digoxin actually increases vagal tone and slows the heart.
C
Correct. A smaller Na+ gradient weakens the exchanger's ability to export Ca2+, so more Ca2+ is stored and released with each beat.
D
Calcium sensitizers are a different drug class.
TakeawayBlock the Na+ pump → raise Na+ inside → keep more Ca2+ → stronger contraction.
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Reviewed 2026-11-05 by a medical student. Spot an error? Report it with question ID bb186.