The intrinsic pathway of apoptosis
In the intrinsic pathway of apoptosis, which event activates the caspase cascade?
Answer A: explanation for every choice
A
Correct. Cytochrome c joins Apaf-1 to form the apoptosome, which activates caspase-9.
B
Fas ligand binding starts the extrinsic, death-receptor pathway.
C
Membrane rupture with inflammation is characteristic of necrosis.
D
Telomerase extends chromosome ends and is not part of apoptosis.
TakeawayIntrinsic apoptosis: mitochondria release cytochrome c → caspase-9.
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Reviewed 2026-11-05 by a medical student. Spot an error? Report it with question ID bb136.