DNA ligase and Okazaki fragments
Which enzyme joins Okazaki fragments on the lagging strand?
Answer D: explanation for every choice
A
Helicase unwinds the double helix at the fork.
B
Primase synthesizes the RNA primers that start each fragment.
C
Topoisomerase relieves supercoiling ahead of the fork.
D
Correct. DNA ligase seals the nicks between fragments by forming phosphodiester bonds.
TakeawayHelicase unwinds, primase primes, polymerase extends, ligase seals.
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Reviewed 2026-11-05 by a medical student. Spot an error? Report it with question ID bb35.