DNA replication vs. transcription
Which feature is true of DNA replication but not of transcription?
Answer C: explanation for every choice
A
Both processes read a DNA template.
B
Both DNA and RNA polymerases synthesize 5′→3′.
C
Correct. DNA polymerase can only extend an existing 3′-OH, so primase first lays down an RNA primer. RNA polymerase starts without a primer.
D
Both occur in the nucleus in eukaryotes.
TakeawayRNA polymerase starts from scratch. DNA polymerase needs a primer's 3′-OH.
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Reviewed 2026-11-05 by a medical student. Spot an error? Report it with question ID bb20.