DNA methylation and gene silencing
Methylation of cytosines in CpG islands near a gene's promoter usually:
Answer C: explanation for every choice
A
Promoter methylation is associated with reduced, not increased, expression.
B
Methylation does not change the DNA sequence, so the protein sequence is unchanged.
C
Correct. Promoter methylation silences genes, as in X inactivation and genomic imprinting.
D
Methylated DNA recruits proteins that promote deacetylation and condensation.
TakeawayPromoter methylation silences genes.
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Reviewed 2026-11-05 by a medical student. Spot an error? Report it with question ID bb47.