Graves' disease and TSH feedback
In Graves' disease, antibodies stimulate the TSH receptor and thyroid hormone levels rise. What happens to TSH levels?
Answer C: explanation for every choice
A
High TSH with low thyroid hormone is the pattern of primary hypothyroidism.
B
Negative feedback lowers TSH when thyroid hormone is high.
C
Correct. High thyroid hormone suppresses TRH and TSH release.
D
Both TRH and TSH are suppressed by high thyroid hormone.
TakeawayPrimary hyperthyroidism: high T4, low TSH.
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Reviewed 2026-11-05 by a medical student. Spot an error? Report it with question ID bb91.