Insulin and GLUT4
Insulin increases glucose uptake in skeletal muscle and adipose tissue mainly by:
Answer A: explanation for every choice
A
Correct. Insulin signaling triggers fusion of vesicles that carry GLUT4 with the cell membrane.
B
GLUT2 in the liver is insulin-independent.
C
SGLTs are found in the intestine and kidney, not in insulin-regulated muscle uptake.
D
Glucose is polar and needs a transporter to cross membranes.
TakeawayInsulin-sensitive glucose uptake = GLUT4 in muscle and fat.
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Reviewed 2026-11-05 by a medical student. Spot an error? Report it with question ID bb113.