Why SSRIs take weeks to work
SSRIs block serotonin reuptake within hours, but mood usually improves only after several weeks. This delay suggests that:
Answer A: explanation for every choice
A
Correct. The mismatch suggests downstream changes, such as receptor regulation and neuroplasticity, drive the benefit.
B
SSRIs reach the brain and block reuptake quickly.
C
The effectiveness of serotonergic drugs implies serotonin is involved, even if the simple deficit model is incomplete.
D
SSRIs are selective for the serotonin transporter.
TakeawayFast synaptic effect, slow clinical effect → downstream adaptation matters.
Next question →
Reviewed 2026-11-05 by a medical student. Spot an error? Report it with question ID ps123.