Fructose metabolism bypasses PFK-1
In the liver, fructose is converted to intermediates that enter glycolysis after the PFK-1 step. What is a consequence of this?
Answer A: explanation for every choice
A
Correct. Without PFK-1 control, excess fructose supplies carbon for acetyl-CoA and triglyceride synthesis.
B
Liver fructose uptake through GLUT2 doesn't depend on insulin.
C
Liver fructose becomes fructose-1-phosphate, then trioses, skipping glucose-6-phosphate.
D
Most fructose is metabolized in the liver.
TakeawayFructose enters below PFK-1, skipping glycolysis's main control point.
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Reviewed 2026-11-05 by a medical student. Spot an error? Report it with question ID bb109.