G6PD deficiency and NADPH
A patient develops hemolytic anemia after taking an oxidizing drug. Which enzyme is most likely deficient, and what does it normally produce?
Answer D: explanation for every choice
A
Pyruvate kinase deficiency also causes hemolysis, but not one triggered by oxidizing drugs.
B
G6PD produces NADPH, not NADH.
C
Transketolase acts in the nonoxidative phase of the pathway and does not make NADPH.
D
Correct. G6PD makes NADPH, which keeps glutathione reduced to protect red cells from oxidative damage.
TakeawayG6PD → NADPH → reduced glutathione → protection from oxidants.
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Reviewed 2026-11-05 by a medical student. Spot an error? Report it with question ID bb63.