Brain fuel in prolonged starvation
After about three weeks of starvation, the brain gets a large share of its energy from ketone bodies. What is the main benefit?
Answer C: explanation for every choice
A
Fatty acids don't cross the blood–brain barrier in useful amounts.
B
Liver glycogen is used up within about a day of fasting.
C
Correct. Using ketone bodies lowers the brain's glucose demand, sparing amino acids from muscle that would otherwise be used to make glucose.
D
Blood glucose is maintained at a lower-normal level during starvation.
TakeawayKetone use by the brain spares muscle protein.
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Reviewed 2026-11-05 by a medical student. Spot an error? Report it with question ID bb126.