ATP synthase inhibition slows electron transport
Oligomycin blocks the proton channel of ATP synthase. What happens to electron transport in isolated mitochondria?
Answer A: explanation for every choice
A
Correct. Electron transport and ATP synthesis are coupled. When protons can't flow back through ATP synthase, the gradient grows until pumping becomes unfavorable.
B
Faster electron transport happens with uncouplers, which let protons leak back in.
C
Electron transport depends on proton flow back into the matrix.
D
The chain does not run in reverse under these conditions.
TakeawayRespiratory control: electron transport is limited by the proton gradient.
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Reviewed 2026-11-05 by a medical student. Spot an error? Report it with question ID bb120.