Aspirin and cyclooxygenase
Low-dose aspirin reduces clotting for the life of a platelet. Why?
Answer D: explanation for every choice
A
Lipoxygenase makes leukotrienes and isn't aspirin's main target.
B
Thrombin receptor blockers are a different drug class.
C
Aspirin decreases thromboxane A2, which promotes platelet aggregation.
D
Correct. Without a nucleus, platelets can't replace the inactivated COX, so thromboxane A2 production stays low for about 7–10 days.
TakeawayAspirin: irreversible COX inhibition. Anucleate platelets can't recover.
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Reviewed 2026-11-05 by a medical student. Spot an error? Report it with question ID bb163.