Malonyl-CoA inhibits carnitine acyltransferase I
Malonyl-CoA keeps newly made fatty acids from being oxidized right away. It does this by inhibiting:
Answer C: explanation for every choice
A
Acetyl-CoA carboxylase makes malonyl-CoA. It is not inhibited by its own product in this way.
B
Fatty acid synthase uses malonyl-CoA as a substrate.
C
Correct. Blocking CPT-1 prevents fatty acids from entering mitochondria for β-oxidation while synthesis is active.
D
Hormone-sensitive lipase releases fatty acids from stored triglycerides and is regulated hormonally.
TakeawayMalonyl-CoA blocks fatty acid entry into mitochondria.
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Reviewed 2026-11-05 by a medical student. Spot an error? Report it with question ID bb66.