How statins lower LDL
Statins lower blood LDL cholesterol. What is their mechanism?
Answer A: explanation for every choice
A
Correct. Less cholesterol synthesis lowers liver cholesterol, which increases LDL receptor expression and clears more LDL from the blood.
B
Blocking intestinal absorption is how ezetimibe works.
C
Lipoprotein lipase mainly clears triglycerides.
D
Acetyl-CoA carboxylase controls fatty acid synthesis, not cholesterol synthesis.
TakeawayStatins block HMG-CoA reductase, the rate-limiting step of cholesterol synthesis.
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Reviewed 2026-11-05 by a medical student. Spot an error? Report it with question ID bb117.